Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects
Hiroyasu Takemoto, Takanori Inaba, Takahiro Nomoto, Makoto Matsui, Xiaomeng Liu, Masahiro Toyoda, Yuto Honda, Kaori Taniwaki, Naoki Yamada, Junhyun Kim, Keishiro Tomoda, Nobuhiro Nishiyama
Topics & Concepts
GemcitabineConjugateConjugated systemPotencyPharmacologyAcetalDistribution (mathematics)ChemistryApoptosisDrug deliveryDrugCancer researchPolymerMaterials scienceStereochemistryMedicineChemotherapyNanotechnologyBiochemistryIn vitroInternal medicineMathematicsMathematical analysisOrganic chemistryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsGraphene and Nanomaterials Applications