Therapeutic targeting of eukaryotic initiation factor (eIF) 4E
Jerry Pelletier, Nahum Sonenberg
Abstract
Fundamental studies unraveled the role of eukaryotic initiation factor (eIF) 4E in mRNA translation and its control. Under physiological conditions, regulation of translation by eIF4E is essential to cellular homeostasis. Under stress, gene flow information is parsed by eIF4E to support adaptive mechanisms that favor cell survival. Dysregulated eIF4E activity fuels tumor formation and progression and modulates response to therapy. Thus, there has been heightened interest in understanding eIF4E function in controlling gene expression as well as developing strategies to block its activity to treat disease.
Topics & Concepts
EIF4EEukaryotic translationTranslation (biology)Eukaryotic initiation factorInitiation factorEIF4EBP1Eukaryotic translation initiation factor 4 gammaEIF4A1eIF2BiologyCell biologyGeneCancer researchMessenger RNAGeneticsPI3K/AKT/mTOR signaling in cancerPolyamine Metabolism and ApplicationsCRISPR and Genetic Engineering