Chromobox 4 (CBX4) promotes tumor progression and stemness via activating CDC20 in gastric cancer
Wen Li, Honghui Chen, Zheng-Gen Wang, Jingjing Liu, Xinan Lei, Wen Chen
Abstract
Background: The Chromobox homolog 4 (CBX4) has been found to be overexpressed in multiple malignancies. However, the associations between CBX4 and gastric cancer (GC) have remained unclear. This study aimed to determine the biological roles of CBX4 in GC and identify effective therapeutic targets. Methods: growth ability of GC. Results: . Conclusions: This study highlights the oncogenic roles of CBX4 in GC. CBX4 activates CDC20 to maintain stemness features of GC, thereby creating therapeutic vulnerabilities in the treatment of GC.
Topics & Concepts
BiologyCancer researchChromatin immunoprecipitationCell growthMolecular biologyCancerMTT assayCarcinogenesisGeneGene expressionGeneticsPromoterEpigenetics and DNA MethylationCancer-related gene regulationRNA modifications and cancer