Nitric Oxide Signaling for Actinorhodin Production in Streptomyces coelicolor A3(2) via the DevS/R Two-Component System
Sota Honma, Shinsaku Ito, Shunsuke Yajima, Yasuyuki Sasaki
Abstract
Diverse organisms, such as mammals, plants, and bacteria, utilize NO via well-known signal transduction mechanisms. Many useful secondary metabolite-producing bacteria of the Streptomyces genus had been also suggested for the metabolism regulated by endogenously produced NO; however, the regulatory mechanisms remain to be elucidated.
Topics & Concepts
Streptomyces coelicolorActinorhodinBiologySecondary metabolismStreptomycesBiochemistryDEVSCell signalingRegulonSignal transductionCell biologyBacteriaRegulation of gene expressionGeneBiosynthesisGeneticsSystems engineeringEngineeringModeling and simulationMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesMicrobial Community Ecology and Physiology