Assessment of proarrhythmogenic risk for chloroquine and hydroxychloroquine using the CiPA concept
Urs Thomet, Bogdan Amuzescu, Thomas Knott, Stefan A. Mann, Kanigula Mubagwa, Beatrice Mihaela Radu
Topics & Concepts
ProarrhythmiaHydroxychloroquineChloroquinehERGIC50PharmacologyPatch clampIn vitroMedicineVoltage clampChemistryElectrophysiologyBiophysicsInternal medicineDrugBiologyBiochemistryMalariaImmunologyPotassium channelCoronavirus disease 2019 (COVID-19)DiseaseInfectious disease (medical specialty)Drug-Induced Ocular ToxicityCardiac electrophysiology and arrhythmiasAntibiotics Pharmacokinetics and Efficacy