OptDesign: Identifying Optimum Design Strategies in Strain Engineering for Biochemical Production
Shouyong Jiang, Irene Otero‐Muras, Julio R. Banga, Yong Wang, Marcus Kaiser, Natalio Krasnogor
Abstract
using the latest genome-scale metabolic model iML1515, showing highly consistent results with previous studies while suggesting new manipulations to boost strain performance. The source code is available at https://github.com/chang88ye/OptDesign.
Topics & Concepts
Metabolic engineeringSynthetic biologyStrain (injury)Production (economics)Escherichia coliMaximizationComputational biologyComputer sciencePhenotypeGene deletionBiochemical engineeringFlux (metallurgy)GeneFlux balance analysisBiologyBiotechnologyGeneticsMathematical optimizationMathematicsEngineeringChemistryEconomicsAnatomyMacroeconomicsMutantOrganic chemistryMicrobial Metabolic Engineering and BioproductionBiofuel production and bioconversionViral Infectious Diseases and Gene Expression in Insects