Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial
Stephen Milne, Xuan Li, Chen Xi Yang, Fernando Sergio Leitão Filho, Ana I. Hernández Cordero, Cheng Wei Tony Yang, Tawimas Shaipanich, Stephan F. van Eeden, Janice M. Leung, Stephen Lam, Don D. Sin
Abstract
<b>In a RCT of 63 patients with COPD, 12 weeks of ICS/LABA therapy downregulated bronchial epithelial expression of the SARS-CoV-2-related genes <i>ACE2</i> and <i>ADAM17</i> compared to LABA alone. This may have implications for COVID-19 susceptibility/severity in COPD.</b>https://bit.ly/3vZnBVO
Topics & Concepts
MedicineCOPDRandomized controlled trialDownregulation and upregulationInhaled corticosteroidsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Corticosteroid2019-20 coronavirus outbreakGeneInternal medicineImmunologyVirologyAsthmaGeneticsBiologyOutbreakDiseaseInfectious disease (medical specialty)Chronic Obstructive Pulmonary Disease (COPD) ResearchRespiratory Support and MechanismsCOVID-19 Clinical Research Studies