Intramolecular Chalcogenylation of Isooxazolines Mediated by PhICl2 and Diorganyl Disulfides or Diselenides
Fengxia Sun, Yunfei Du, Dongke Zhang, Jingran Zhang, Xiaoxian Li, Zhenyang Yu, Yadong Li
Abstract
Abstract Reactive organosulfenyl chlorides (ArSCl) or selenenyl chlorides (ArSeCl), generated in situ from the reaction of PhICl2 with diorganyl disulfides or diselenides, enable the intramolecular oxidative cyclization/chalcogenylation of β,γ-unsaturated oximes, leading to the formation of a series of chalcogenylated isooxazolines in good to excellent yield.
Topics & Concepts
ChemistryIntramolecular forceYield (engineering)Medicinal chemistryCombinatorial chemistryPhotochemistryOrganic chemistryMaterials scienceMetallurgySulfur-Based Synthesis TechniquesOrganoselenium and organotellurium chemistryChemical Synthesis and Reactions