Data mining of amine dehydrogenases for the synthesis of enantiopure amino alcohols
Hongyue Wang, Ge Qu, Jun‐Kuan Li, Jun‐An Ma, Jinggong Guo, Yuchen Miao, Zhoutong Sun
Abstract
Five amine dehydrogenases (AmDHs) derived from amino acid dehydrogenases have been identified and evaluated for the stereoselective amination of α-/β-functionalized carbonyl compounds to synthesize chiral amino alcohols.
Topics & Concepts
Enantiopure drugAmine gas treatingAminationChemistryStereoselectivityAmino acidReductive aminationOrganic chemistryCatalysisCombinatorial chemistryEnantioselective synthesisBiochemistryEnzyme Catalysis and ImmobilizationEnzyme Structure and FunctionAsymmetric Hydrogenation and Catalysis