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Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours

Samarth Hegde, Bruno Giotti, Brian Y. Soong, László Halász, Jessica Le Bérichel, Maximilian Schaefer, Benoit Kloeckner, Raphaël Mattiuz, Matthew D. Park, Assaf Magen, Adam Marks, Meriem Belabed, Pauline Hamon, Theodore Chin, Leanna Troncoso, Juliana J. Lee, Kaili Fan, Dughan Ahimovic, Michael J. Bale, Kai Nie, Grace Chung, Darwin D’souza, Krista Angeliadis, Seunghee Kim‐Schulze, Raja M. Flores, Andrew Kaufman, Florent Ginhoux, Jason D. Buenrostro, Steven Z. Josefowicz, Alexander M. Tsankov, Thomas U. Marron, Sai Ma, Brian D. Brown, Miriam Mérad

2025Nature23 citationsDOIOpen Access PDF

Topics & Concepts

MyelopoiesisMyeloidCancer researchProgenitor cellTumor microenvironmentImmunologyBone marrowBiologyHaematopoiesisImmunotherapyImmunosuppressionMedicineMonocyteIRF8Fms-Like Tyrosine Kinase 3Immune systemLung cancerStem cellMacrophageMyeloid-derived Suppressor CellCytotoxic T cellEpigeneticsCytostasisImmune cells in cancerImmune Cell Function and InteractionPhagocytosis and Immune Regulation
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours | Litcius