Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives
Limin Liu, Zhengjie Wang, Chao Gao, Honglin Dai, Xiaojie Si, Yang Zhang, Yaqi Meng, Jiaxin Zheng, Yu Ke, Hong‐Min Liu, Qiurong Zhang
Topics & Concepts
ChemistryTrifluoromethylApoptosisPyrimidineIC50Cell cycleLead compoundMTT assayIn vitroCell growthCell cultureCell cycle checkpointStereochemistryTumor cellsBiochemistryCancer researchBiologyAlkylOrganic chemistryGeneticsSynthesis and biological activityQuinazolinone synthesis and applicationsCancer therapeutics and mechanisms