Towards the rational design of ylide-substituted phosphines for gold(<scp>i</scp>)-catalysis: from inactive to ppm-level catalysis
Jens Handelmann, Chatla Naga Babu, Henning Steinert, Christopher Schwarz, Thorsten Scherpf, Alexander Kroll, Viktoria H. Gessner
Abstract
, which is readily accessible in one step from a simple phosphonium salt, exhibited a high catalyst stability and allowed for turnover numbers up to 20 000 in the hydroamination of a series of different alkynes and amines. Furthermore, the catalyst was also active in more challenging reactions including enyne cyclisation and the formation of 1,2-dihydroquinolines.
Topics & Concepts
CatalysisYlideRational designChemistryColloidal goldCombinatorial chemistryOrganic chemistryMaterials scienceNanotechnologyNanoparticleCatalytic Alkyne ReactionsAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods