Discovery of 4-((4-(4-(3-(2-(2,6-difluorophenyl)-4-oxothiazolidin-3-yl)ureido)-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)-N,N-diethylpiperidine-1-carboxamide as kinase inhibitor for the treatment of colorectal cancer
Yuting Zhou, Xingwei Xu, Fei Wang, Huan He, Baohui Qi
Topics & Concepts
ChemistryRegorafenibCytotoxicityCarboxamideApoptosisPharmacologyKinaseQuinolineMTT assayContext (archaeology)IC50ToxicityIn vitroStereochemistryBiochemistryInternal medicineMedicineBiologyColorectal cancerCancerOrganic chemistryPaleontologyPI3K/AKT/mTOR signaling in cancerSynthesis and biological activityQuinazolinone synthesis and applications