Cobalt-catalyzed asymmetric phospha-Michael reaction of diarylphosphine oxides for the synthesis of chiral organophosphorus compounds
Xu-Hui Yu, Liang‐Qiu Lu, Zhihan Zhang, De‐Qing Shi, Wen‐Jing Xiao
Abstract
A cobalt-catalyzed imidazolyl-directed asymmetric phospha-Michael-type reaction for synthesizing chiral organophosphorus compounds is presented. This protocol features broad substrate scope, good functional group tolerance, and mild conditions.
Topics & Concepts
ChemistryCobaltCatalysisMichael reactionSubstrate (aquarium)Functional groupEnantioselective synthesisCombinatorial chemistryScope (computer science)Organic chemistryPolymerGeologyComputer scienceOceanographyProgramming languageAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisAxial and Atropisomeric Chirality Synthesis