The <i>de novo</i> Purine Biosynthesis Pathway Is the Only Commonly Regulated Cellular Pathway during Biofilm Formation in TSB-Based Medium in Staphylococcus aureus and Enterococcus faecalis
Martin Gélinas, Léa Museau, Arielle Milot, Pascale B. Beauregard
Abstract
purine biosynthesis pathway was upregulated during biofilm formation by both species in a specific medium. The requirement for purine could constitute an interesting new anti-biofilm target with a wide spectrum that could also prevent resistance evolution. These results are also relevant to a better understanding of the physiology of biofilm formation.
Topics & Concepts
BiofilmMicrobiologyEnterococcus faecalisBiosynthesisPurineBiologyMetabolic pathwayStaphylococcus aureusBacteriaAntibioticsPurine metabolismTranscriptomeEnzymeSignal transductionGeneAntibiotic resistanceEnterococcusMultidrug toleranceChemistryBiological pathwayNucleotide salvageBiochemistryDrug resistanceBacterial biofilms and quorum sensingAntimicrobial Resistance in StaphylococcusAntimicrobial agents and applications