FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity
Paolo Governa, Maria Cristina Caroleo, Gabriele Carullo, Francesca Aiello, Erika Cione, Fabrizio Manetti
Topics & Concepts
Free fatty acid receptor 1ChemistryPharmacologyDrug discoveryPhospholipidosisToxicityAllosteric regulationReceptorAgonistBiochemistryMedicineMembranePhospholipidOrganic chemistryDiabetes Treatment and ManagementReceptor Mechanisms and SignalingPancreatic function and diabetes