Visible-Light-Promoted Synthesis of α-CF<sub>2</sub>H-Substituted Ketones by Radical Difluoromethylation of Enol Acetates
Zengqiang Feng, Baoxiang Zhu, Bingbing Dong, Li Cheng, Yunpu Li, Zechao Wang, Junliang Wu
Abstract
An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of α-CF2H-substituted ketones has been described. Upon irradiation under blue LED with catalytic amounts of fac-Ir(ppy)3, this photocatalytic procedure employs difluoromethyltriphenylphosphonium bromide as a radical precursor. Various α-CF2H-substituted ketones are successfully created via designed systems based on the SET process. The methodology has also provided an operationally simple process with broad functional group compatibility.
Topics & Concepts
ChemistryEnolPhotocatalysisBromideVisible spectrumCatalysisPhotochemistryCombinatorial chemistryOrganic chemistryPhysicsOptoelectronicsFluorine in Organic ChemistryRadical Photochemical ReactionsInorganic Fluorides and Related Compounds