PRMT5 Facilitates Infectious Bursal Disease Virus Replication through Arginine Methylation of VP1
Xifeng Hu, Zheng Chen, Xiangdong Wu, Qiuling Fu, Zhen Chen, Yu Huang, Huansheng Wu
Abstract
Post-translational modification of infectious bursal disease virus (IBDV) VP1 is important for the regulation of its polymerase activity. Investigation of the significance of specific modification of VP1 can lead to better understanding of viral replication and can probably also help in identifying novel targets for antiviral compounds. Our work demonstrates the molecular mechanism of VP1 methylation mediated by PRMT5, which is critical for viral polymerase activity, as well as viral replication. Our study expands a novel insight into the function of arginine methylation of VP1, which might be useful for limiting the replication of IBDV.
Topics & Concepts
BiologyViral replicationProtein arginine methyltransferase 5Infectious bursal diseasePolymeraseVirologyVirusMethylationMethyltransferaseGeneticsVirulenceGeneCancer-related gene regulationHate Speech and Cyberbullying DetectionVirology and Viral Diseases