Effects of menstrual cycle and menopause on internal carotid artery shear-mediated dilation in women
Erika Iwamoto, Rintaro Sakamoto, Wakako Tsuchida, Kotomi Yamazaki, Tatsuki Kamoda, Toru Neki, Masaki Katayose, Darren P. Casey
Abstract
The present study evaluated the effects of the menstrual cycle and menopause stages on the shear-mediated dilation of the ICA, a potential index of cerebrovascular endothelial function, in pre-, peri-, and postmenopausal women. Shear-mediated dilation of the ICA was increased from the low- to high-estradiol phases in naturally cycling premenopausal women and was reduced with advancing menopause stages. Furthermore, lower estradiol was associated with reduced shear-mediated dilation of the ICA, independent of age.
Topics & Concepts
MenopauseMenstrual cycleInternal carotid arteryMedicineInternal medicineCardiologyHormoneCardiovascular Health and Disease PreventionCardiovascular Disease and AdiposityCerebrovascular and Carotid Artery Diseases