Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization
Le Yu, Jun Feng Zhang, Mingle Li, Dewei Jiang, Ying Zhou, Peter Verwilst, Jong Seung Kim
Abstract
We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.
Topics & Concepts
Intramolecular forceVisualizationConjugateViscosityBiophysicsFluorescenceChemistryComputer sciencePhysicsBiologyArtificial intelligenceStereochemistryOpticsThermodynamicsMathematicsMathematical analysisNanoplatforms for cancer theranosticsAdvanced Fluorescence Microscopy TechniquesLuminescence and Fluorescent Materials