Dopamine-loaded Poly (butyl cyanoacrylate) Nanoparticles Reverse Behavioral Deficits in Parkinson’s Animal Models
Fatemeh Jahansooz, Bahman Ebrahimi Hosseinzade, Ashrafalsadat Hatamian Zarmi, Fatemeh Hadi, Seyed Mohammad Masood Hojjati, Koorosh Shahpasand
Abstract
Aim: Parkinson's disease (PD) is a neurological disorder resulting from decreased dopamine (DA) secretion in the brain, which reflects impaired motor function. Thus, a drug-delivery system for releasing DA into the brain would be of crucial importance. Materials & methods: We herein examined the in vivo drug efficiency of novel poly-butyl-cyanoacrylate nanoparticles loaded with DA (DA-PBCA NPs). Results & conclusion: The NPs were able to pass through the blood–brain barrier and improve brain structure and function in the PD animal models. Moreover, we found a reduced α-synucleinopathy in the animal model brains after the NPs administration. Thus, the NPs seem to be a reliable DA delivery system for treating PD patients.