Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition
Zhenyu Ji, Ching-Ni Jenny Njauw, Samantha Guhan, Raj Kumar, Bobby Y. Reddy, Anpuchchelvi Rajadurai, Keith T. Flaherty, Hensin Tsao
Topics & Concepts
VemurafenibCancer researchGefitinibEpidermal growth factor receptorReceptor tyrosine kinaseEGFR inhibitorsDabrafenibKinaseTyrosine kinaseMelanomaTyrosine-kinase inhibitorSignal transductionBiologyMedicineInternal medicineReceptorCell biologyCancerMetastatic melanomaMelanoma and MAPK PathwaysComputational Drug Discovery MethodsCytokine Signaling Pathways and Interactions