Immune checkpoint inhibitor‐related haemophagocytic lymphohistiocytosis in a patient with non‐small cell lung carcinoma
Setsuko Oyama, Tatsuya Shirai, Yukiko Abe, Maya Tsuchiya, Toshiya Inui, Kozo Suhara, Satoshi Noto, Mitsuhiro Kamimura
Abstract
Hemophagocytic lymphohistiocytosis (HLH) has been reported as a rare complication of immune checkpoint inhibitors (ICI); however, ICI-related HLH is a life-threatening and comparatively late adverse event. Early diagnosis is critical, and it should be included in the differential diagnosis especially in patients with cytopenia with fever and hyperferritinaemia.
Topics & Concepts
Hemophagocytic lymphohistiocytosisCytopeniaMedicineComplicationAdverse effectImmune systemImmune checkpointNivolumabImmunologyInternal medicineImmunotherapyDiseaseBone marrowAutoimmune and Inflammatory Disorders ResearchImmune Cell Function and InteractionParvovirus B19 Infection Studies