Photoredox-Catalyzed Benzylic Esterification via Radical-Polar Crossover
Bumpei Maeda, Yota Sakakibara, Kei Murakami, Kenichiro Itami
Abstract
Photoredox-catalyzed C-O bond formation reactions are reported. The decarboxylative esterification reaction allows the conversion of a variety of arylacetic acids into the corresponding benzyl carboxylates. Furthermore, the use of (diacetoxyiodo)benzene allows the conversion of the benzylic C-H bond through hydrogen atom transfer. The reactions were applied to the divergent transformation of pharmaceuticals via decarboxylative or C-H esterification reactions.
Topics & Concepts
ChemistryPolarCatalysisCrossoverPhotoredox catalysisCombinatorial chemistryPhotochemistryOrganic chemistryPhotocatalysisPhysicsAstronomyArtificial intelligenceComputer scienceRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques