Abandoning the Proteinopathy Paradigm in Parkinson Disease
Alberto J. Espay, Michael S. Okun
Abstract
This Viewpoint makes a case for changing the approach in Parkinson disease research efforts from one of proteinopathy (accrual of amyloids) to proteinopenia (depletion of normal proteins).
Topics & Concepts
Parkinson's diseaseDiseaseAccrualNeuroscienceCognitive sciencePsychologyBiologyMedicinePathologyBusinessAccountingEarningsParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsNeurological disorders and treatments