ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response
Aslı Yıldırım, Mevlut Citir, Asli E. Atici, Zehra Veli, Zehra Yıldırım, Özlem Tufanlı, Alexis Traynor‐Kaplan, Carsten Schultz, Ebru Erbay
Abstract
activation in mammalian cells. Our data further demonstrate that inhibition of the IRE1-SPL axis abrogates the activation of two eif2α kinases, namely double-stranded RNA-activated protein kinase (PKR) and PKR-like ER kinase upon ER stress. These findings show that the IRE1-SPL axis plays a central role in coordinating the adaptive responses of ER and mitochondria to ER stress in mammalian cells.
Topics & Concepts
Unfolded protein responseEndoplasmic reticulumCell biologyProtein kinase RIntegrated stress responseSphingosine kinaseEIF-2 kinaseKinaseBiologyProtein kinase APhosphorylationSphingosine kinase 1SphingosineBiochemistryMitogen-activated protein kinase kinaseTranslation (biology)Sphingosine-1-phosphateCyclin-dependent kinase 2Messenger RNAGeneReceptorEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyCellular transport and secretion