Ductular Reaction and Liver Regeneration: Fulfilling the Prophecy of Prometheus!
Satdarshan P. Monga, Kari Nejak‐Bowen
Abstract
Many acute and chronic liver injuries exhibit histologically as proliferating cholangiocytes, commonly referred to as ductular reaction. The origin of the cells comprising the ductular reaction is dependent on the injury (hepatocyte vs cholangiocyte) and capability of these 2-liver epithelial or “hepithelial” cells to divide and replace injured cells. The role of ductular reaction in hepatobiliary injury versus repair remains debated. Although ductular reaction has been shown to be a source of proinflammatory and profibrogenic factors, it has also been shown to contribute toward maintaining hepatobiliary function during injury.
Topics & Concepts
HepatocyteCholangiocyteRegeneration (biology)Liver injuryCancer researchMedicineCell biologyBiologyPathologyChemistryInternal medicineBiochemistryIn vitroOrgan Transplantation Techniques and OutcomesLiver physiology and pathologyLiver Disease and Transplantation