Sirt1 during childhood is associated with microvascular function later in life
Paula Rodriguez‐Miguelez, Jacob Looney, Jeffrey Thomas, Gregory A. Harshfield, Jennifer S. Pollock, Ryan A. Harris
Abstract
With a longitudinal cohort, novel observations from the present study demonstrate that individuals who had lower Sirt1 early in life exhibit premature microvascular dysfunction during adulthood and may be at higher risk to develop CVD. These results provide experimental evidence that Sirt1 may play an important role in microvascular function with age and represent a potential therapeutic target to prevent premature vascular dysfunction.
Topics & Concepts
MedicineCohortCohort studyPediatricsGerontologyInternal medicineCardiologyCardiovascular Disease and AdiposityAdipose Tissue and MetabolismSirtuins and Resveratrol in Medicine