Electrochemical C–H Alkylation of Azauracils Using <i>N</i>-(Acyloxy)phthalimides
Rupashri Dash, Satya Prakash Panda, Kuldeep Singh Bhati, Siddharth Sharma, Sandip Murarka
Abstract
-(acyloxy)phthalimides (NHPI esters) as readily available alkyl radical progenitors under metal- and additive-free conditions. Several azauracils are shown to undergo alkylation with an array of NHPI esters (1°, 2°, 3°, and sterically congested), providing the desired products in good to excellent yields. This operationally simple method is robust, scalable, and suitable for both batch and flow setups.
Topics & Concepts
ChemistryPhthalimidesAlkylationElectrochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisPhthalimideElectrodePhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques