Relevance of the electron transfer pathway in photodynamic activity of Ru(<scp>ii</scp>) polypyridyl complexes containing 4,7-diphenyl-1,10-phenanthroline ligands under normoxic and hypoxic conditions
Olga Mazuryk, Ewelina Janczy-Cempa, Justyna Łagosz, Dorota Rutkowska‐Zbik, Agata Machnicka, Aneta Krasowska, Piotr Pietrzyk, Grażyna Stochel, Małgorzata Brindell
Abstract
, highlighting the importance of electron-transfer processes in the observed photodynamic activity of Ru polypyridyl complexes. A combination of photodynamic activity with cytotoxicity under decreased dioxygen concentrations may help overcome the current photodynamic therapy (PDT) limitation. The findings highlight the need for broadening the scope of tested Ru-based photosensitizers.
Topics & Concepts
ChemistryPhototoxicityPhotodynamic therapyPhenanthrolineQuinoxalineContext (archaeology)CytotoxicityReactive oxygen speciesPhotochemistryElectron transferSinglet oxygenFluorescenceCombinatorial chemistryStereochemistryIn vitroOxygenBiochemistryOrganic chemistryBiologyPhysicsPaleontologyQuantum mechanicsMetal complexes synthesis and propertiesPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry