Ecofriendly densitometric RP-HPTLC method for determination of rivaroxaban in nanoparticle formulations using green solvents
Prawez Alam, Essam A. Ali, Muzaffar Iqbal, Md. Khalid Anwer, G. Mostafa, Mohammed H. Alqarni, Ahmed I. Foudah, Faiyaz Shakeel
Abstract
+ 1189.4. The proposed RP-HPTLC technique was validated for "precision, accuracy, robustness and sensitivity". The accuracy of the method was obtained as 97.97-99.67%. The % RSD in repeatability and intermediate precision was recorded as 0.46-0.64 and 0.48-0.86%, respectively. The LOD and LOQ for rivaroxaban were obtained as 18.45 and 55.35 ng per spot, respectively. The % content of rivaroxaban in marketed tablets and NPs was recorded as 99.20 and 98.08%, respectively. The proposed RP-HPTLC technique could be successfully applied for the pharmaceutical assay of rivaroxaban in NPs, marketed tablets and related formulations.