Discovery of a novel Coumarin-Dihydroquinoxalone derivative MY-673 as a tubulin polymerization inhibitor capable of inhibiting the ERK pathway with potent anti-gastric cancer activities
Jian Song, Shuyu Wang, Xiao Wang, Mei-Qi Jia, Xin-Yi Tian, Xiang-Jing Fu, Cheng‐Yun Jin, Sai‐Yang Zhang
Topics & Concepts
MAPK/ERK pathwayChemistryKinaseIn vivoPharmacologyCancer cellCancer researchCell growthCancerBiochemistryBiologyGeneticsBiotechnologySynthesis and biological activityMelanoma and MAPK PathwaysCancer Mechanisms and Therapy