Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue
Maria Andersen, Sebastian Krossa, Therese S. Høiem, Rebecca Buchholz, Britt S. R. Claes, Benjamin Balluff, Shane R. Ellis, Elin Richardsen, Helena Bertilsson, Ron M. A. Heeren, Tone F. Bathen, Uwe Kärst, Guro F. Giskeødegård, May‐Britt Tessem
Abstract
fold change range: -0.423 to -0.987), while no significant difference between cancer and stroma tissue was found. Simultaneous spatial detection of zinc and its metabolites is not only a valuable tool for analyzing the role of zinc in prostate metabolism but might also provide a fast and simple method to detect zinc, citrate, and aspartate levels as a biomarker signature for prostate cancer diagnostics and prognostics.
Topics & Concepts
ChemistryProstate cancerProstateZincMass spectrometryCancerMatrix-assisted laser desorption/ionizationBiomarkerChromatographyBiochemistryInternal medicineDesorptionMedicineAdsorptionOrganic chemistryMass Spectrometry Techniques and ApplicationsTrace Elements in HealthX-ray Spectroscopy and Fluorescence Analysis