Chondroitin Sulfate Proteoglycans Are De Facto Cellular Receptors for Human Papillomavirus 16 under High Serum Conditions
Nathan R. Fons, Rhonda C. Kines, Cynthia D. Thompson, Patricia M. Day, Douglas R. Lowy, John T. Schiller
Abstract
Heparan sulfate proteoglycans (HSPGs) have previously been identified as primary attachment factors for the initial binding of human papillomaviruses (HPVs) prior to infection. Here, we demonstrate that in vitro , HPV binding to HSPGs is strongly dependent on the surrounding experimental conditions, including the concentration of fetal bovine serum (FBS).
Topics & Concepts
BiologyChondroitin sulfateReceptorFetal bovine serumGene knockdownCell biologyCell cultureHeparan sulfateCellGlycosaminoglycanBiochemistryGeneGeneticsProteoglycans and glycosaminoglycans researchCervical Cancer and HPV ResearchFibroblast Growth Factor Research