Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS <sup>G12D</sup> Inhibitor
Xiaolun Wang, Shelley Allen, James F. Blake, Vickie Bowcut, David M. Briere, Andrew Calinisan, Joshua R. Dahlke, Jay B. Fell, John P. Fischer, Robin J. Gunn, Jill Hallin, Jade Laguer, J. David Lawson, James Medwid, Brad Newhouse, Phong Nguyen, Jacob M. O’Leary, Peter Olson, Spencer Pajk, Lisa Rahbæk, Mareli Rodriguez, Christopher R. Smith, Tony P. Tang, Nicole C. Thomas, Darin Vanderpool, Guy Vigers, James G. Christensen, Matthew A. Marx
Abstract
mutant xenograft mouse tumor model.
Topics & Concepts
KRASChemistryMutantCancer researchMutationBiochemistryBiologyGeneProtein Kinase Regulation and GTPase SignalingEnzyme Structure and FunctionMelanoma and MAPK Pathways