Direct Amination of Benzylic Pinacol Boronates by an Aminoazanium
Chao Liu, Jianeng Xu, Yucheng Qin
Abstract
Abstract A practical stereospecific direct amination of benzylic pinacol boronates was achieved by using 4-amino-4-methylmorpholinium iodide as a new amination reagent and cesium carbonate as the base. After amination, an in situ reductive N-alkylation with an aldehyde proceeded well to produce secondary amines.
Topics & Concepts
ChemistryPinacolAminationReagentReductive aminationAlkylationOrganic chemistryElectrophilic aminationAldehydeIodideStereospecificityCombinatorial chemistryCatalysisOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods