Green Bio‐organic and Recoverable Catalyst Taurine (2‐aminoethanesulfonic acid) for Synthesis of Bio‐active Compounds 3,4‐Dihydropyrimidin Derivatives in Aqueous Medium.
Mahmoud Abd El Aleem Ali Ali El‐Remaily, Omar M. Elhady
Abstract
Abstract A highly green bio‐organic catalyst known as Taurine (2‐aminoethanesulfonic acid) is plentifully in the tissues of humans and animals and is an efficient and environmentally benign catalyst for the one‐pot multicomponent reaction synthesis of bio‐active 3,4‐dihydropyrimidin‐2(1H)‐ones/thiones (Biginelli Reaction) in aqueous medium. The advantages of this protocol by way of the Taurine catalyst are that it is eco‐friendly, commercially available, low cost, has high reusability, short reaction times, high yields and the products obtained high purities without using any organic solvents.
Topics & Concepts
TaurineCatalysisReusabilityChemistryBiginelli reactionEnvironmentally friendlyAqueous mediumOrganic chemistryAqueous solutionGreen chemistryCombinatorial chemistryIonic liquidAmino acidBiochemistryComputer scienceBiologyProgramming languageEcologySoftwareMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds