PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm
Sharon Muggeo, Laura Crisafulli, Paolo Uva, Elena Fontana, Marta Ubezio, Emanuela Morenghi, Federico Colombo, Rosita Rigoni, Clelia Peano, Paolo Vezzoni, Matteo Giovanni Della Porta, Anna Villa, Francesca Ficara
Abstract
mutation. Modulation of the PBX1-driven transcriptional program might represent a novel therapeutic approach.
Topics & Concepts
BiologyMyeloproliferative neoplasmStem cellMyelopoiesisCancer researchHaematopoiesisGranulocytosisProgenitor cellMyeloidTranscriptomeSomatic cellMutationMyelofibrosisCell biologyImmunologyGeneticsBone marrowGeneGene expressionGranulocyteMyeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia ResearchEosinophilic Disorders and Syndromes