Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease
Xiaodong Dou, Qi Sun, Guofeng Xu, Yameng Liu, Caifang Zhang, Bingding Wang, Yangbin Lu, Zheng Guo, Lingyu Su, Tongyu Huo, Xinyi Zhao, Chen Wang, Zhongtian Yu, Song Song, Liangren Zhang, Zhenming Liu, Luhua Lai, Ning Jiao
Topics & Concepts
ChemistryHydrazine (antidepressant)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ProteaseFuranVirology2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Combinatorial chemistryStereochemistryEnzymeBiochemistryOrganic chemistryPathologyInfectious disease (medical specialty)DiseaseMedicineOutbreakBiologySynthesis and biological activityComputational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic Compounds