Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 <sup>+</sup> T cells
Anthony Kusnadi, Ciro Ramírez-Suástegui, Vicente Fajardo, Serena Chee, Benjamin J. Meckiff, Hayley Simon, Emanuela Pelosi, Grégory Seumois, Ferhat Ay, Pandurangan Vijayanand, Christian H. Ottensmeier
Abstract
Fewer SARS-CoV-2–reactive memory CD8 + T cells with “exhaustion” features are present in patients with severe versus mild COVID-19.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVirologySars virusCD8MedicineImmunologyBiologyPathologyOutbreakImmune systemDiseaseInfectious disease (medical specialty)Long-Term Effects of COVID-19Infection Control and VentilationCOVID-19 Clinical Research Studies