Molecular mechanism of action of new 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles with cytotoxic and selective effect against oral squamous cell carcinoma
Ingrid Cavalcanti Chipoline, Anna Carolina Carvalho da Fonseca, Gabriella Ribeiro Machado da Costa, Michele Pereira de Souza, Vitor Won‐Held Rabelo, Lucas Nicolau de Queiroz, Theo Luiz Ferraz de Souza, Elan Cardozo Paes de Almeida, Paula Alvarez Abreu, Bruno Pontes, Vı́tor F. Ferreira, Fernando de Carvalho da Silva, Bruno Kaufmann Robbs
Topics & Concepts
CarboplatinIn vivoCytotoxicityChemistryCisplatinCytotoxic T cellToxicitySquamous carcinomaPharmacologyCancer cellCell cultureIn vitroMechanism of actionCancerCellCancer researchBiochemistryCarcinomaBiologyMedicinePathologyChemotherapyInternal medicineBiotechnologyOrganic chemistryGeneticsCancer therapeutics and mechanismsBioactive Compounds and Antitumor AgentsSynthesis and biological activity