Prognostic Value of Coronary CT Angiography-Derived Fractional Flow Reserve in Non-obstructive Coronary Artery Disease: A Prospective Multicenter Observational Study
Fan Zhou, Qian Chen, Xiao Luo, Wei Cao, Ziwen Li, Bo Zhang, U. Joseph Schoepf, Callum E. Gill, Lili Guo, Hong Gao, Qingyao Li, Yibing Shi, Tingting Tang, Xiaochen Liu, Hong-Lin Wu, Dongqing Wang, Feng Xu, Dongsheng Jin, Sheng Huang, Haige Li, Changjie Pan, Hongmei Gu, Lixiang Xie, Ximing Wang, Jing Ye, Jianwei Jiang, Hanqing Zhao, Xiangming Fang, Yi Xu, Wei Xing, Xiaohu Li, Xindao Yin, Guangming Lu, Long Jiang Zhang
Abstract
Coronary artery disease (CAD) is a major contributor to morbidity and mortality worldwide. Myocardial ischemia may occur in patients with normal or non-obstructive CAD on invasive coronary angiography (ICA). The comprehensive evaluation of coronary CT angiography (CCTA) integrated with fractional flow reserve derived from CCTA (CT-FFR) to CAD may be essential to improve the outcomes of patients with non-obstructive CAD. China CT-FFR Study-2 (ChiCTR2000031410) is a large-scale prospective, observational study in 29 medical centers in China. The primary purpose is to uncover the relationship between the CCTA findings (including CT-FFR) and the outcome of patients with non-obstructive CAD. At least 10,000 patients with non-obstructive CAD but without previous revascularization will be enrolled. A 5-year follow-up will be performed. The primary endpoint is the occurrence of major adverse cardiovascular events (MACE), including all-cause mortality, non-fatal myocardial infarct, unplanned revascularization, and hospitalization for unstable angina. Clinical characteristics, laboratory and imaging examination results will be collected to analyze their prognostic value.