Ex vivo effect of JAK inhibition on JAK-STAT1 pathway hyperactivation in patients with dominant-negative STAT3 mutations
Pilar Blanco-Lobo, Paloma Guisado-Hernández, Isabel Villaoslada, Beatriz de Felipe, Carmen Carreras, Hector Rodriguez‐Villalobos, Begoña Carazo‐Gallego, Ana Méndez‐Echevarría, José Manuel Lucena, Pilar Ortiz Aljaro, María José Castro, José Francisco Noguera-Uclés, Joshua D. Milner, Katelyn McCann, Ofer Zimmerman, Alexandra F. Freeman, Michail S. Lionakis, Steven M. Holland, Olaf Neth, Peter Olbrich
Topics & Concepts
STAT1RuxolitinibJanus kinaseCancer researchBiologyJanus kinase 1STAT3ImmunologyCytokineMedicinePhosphorylationInterferonCell biologyBone marrowMyelofibrosisImmunodeficiency and Autoimmune DisordersCytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis