Nickel catalyzed C–S cross coupling of sterically hindered substrates enabled by flexible bidentate phosphines
Ivo H. Lindenmaier, Robert C. Richter, Ivana Fleischer
Abstract
The challenging nickel-catalyzed coupling of ortho -substituted aryl triflates with thiols was accomplished by employing a versatile bidentate ligand, capable of decoordination of one phosphorus atom during the deprotonation of thiol.
Topics & Concepts
ChemistryDenticityDeprotonationNickelSteric effectsCatalysisArylThiolLigand (biochemistry)Coupling (piping)Combinatorial chemistryPhotochemistryPolymer chemistryMedicinal chemistryStereochemistryOrganic chemistryCrystal structureBiochemistryMetallurgyMaterials scienceIonReceptorAlkylSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions