Individualized chemotherapy guided by the expression of <i>ERCC1, RRM1, TUBB3, TYMS</i> and <i>TOP2A</i> genes versus classic chemotherapy in the treatment of breast cancer: A comparative effectiveness study
Juncheng Li, Peng Sun, Tao Huang, Shengdong He, Lingfan Li, Gang Xue
Abstract
gene expression and use of the results to guide individualized chemotherapy can improve treatment efficacy and reduce unnecessary toxicity.
Topics & Concepts
ERCC1Internal medicineDocetaxelOncologyChemotherapyMedicineBreast cancerHazard ratioRegimenEpirubicinCancerCyclophosphamideBiologyDNA repairConfidence intervalGeneNucleotide excision repairBiochemistryDNA Repair MechanismsCancer Genomics and DiagnosticsLung Cancer Treatments and Mutations