Pyroptotic Macrophage-Derived Microvesicles Accelerate Formation of Neutrophil Extracellular Traps <i>via</i> GSDMD-N-expressing Mitochondrial Transfer during Sepsis
Liangjian Kuang, Yongjian Wu, Jingxian Shu, Jingwen Yang, Haibo Zhou, Xi Huang
Abstract
. Microvesicles-mediated NETs formation depends on the presence of GSDMD-N-expressing mitochondria in the microvesicles. This study elucidates a microvesicles-based pathway for NETs formation during sepsis and proposes a microvesicles-based intervention measure for sepsis management.
Topics & Concepts
MicrovesiclesPyroptosisNeutrophil extracellular trapsCell biologyMacrophageMitochondrionSepsisChemistryReactive oxygen speciesInflammationBiologyImmunologyInflammasomemicroRNAIn vitroBiochemistryGeneNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammasome and immune disordersImmune cells in cancer