PCK2 inhibits lung adenocarcinoma tumor cell immune escape through oxidative stress-induced senescence as a potential therapeutic target
Mingming Tang, Jianjun Sun, Zhigang Cai
Abstract
Background: ) is linked to survival outcomes in lung cancer patients. Methods: in single cells in TCGA lung adenocarcinoma samples. The potential mechanism of action was finally investigated using Gene Set Enrichment Analysis (GSEA) enrichment analysis, Gene Ontology (GO) pathway enrichment analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Results: was involved in the response to oxidative stress-induced senescence, gene silencing, cell cycle, and other biological processes. Conclusions: may be possible since it induces senescence through the oxidative stress response and blocks the immune escape of tumor cells. These results point to a probable target anticancer treatment development in lung adenocarcinoma.