A sequentially activated bioluminescent probe for observation of cellular H<sub>2</sub>O<sub>2</sub> production induced by cysteine
Kaiqing Ma, Yongkang Yue, Lingling Zhao, Jianbin Chao, Caixia Yin
Abstract
We report herein a caged luciferin probe Cy-Hy as a sequentially activated probe to selectively and sensitively sense l -Cys and H 2 O 2 , utilizing the present probe, the cellular excess l -Cys induced H 2 O 2 up-regulation was observed for the first time in the living MDA-MB-231 cells.
Topics & Concepts
BioluminescenceChemistryCysteineLuciferinBiophysicsBiochemistryLuciferaseEnzymeBiologyTransfectionGeneNanoplatforms for cancer theranosticsSulfur Compounds in BiologyAdenosine and Purinergic Signaling