Nitric oxide scavengers based on <i>o</i>-phenylenediamine for the treatment of rheumatoid arthritis
Yeong Mi Lee, 이상기, Won Jong Kim
Abstract
. Depleted levels of NO and reduced levels of pro-inflammatory cytokines by N-Me demonstrated remarkable therapeutic efficacy against joint damage and delayed severity in a collagen-induced arthritis (CIA) model. Therefore, our findings suggest that N-Me is a new NO scavenger with great potential for RA treatment and further clinical drug development.
Topics & Concepts
Rheumatoid arthritisNitric oxideChemistryArthritisPharmacologyCombinatorial chemistryImmunologyMedicineOrganic chemistrySynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activitySynthesis and Reactivity of Sulfur-Containing Compounds