DNA binding, antitubercular, antibacterial and anticancer studies of newly designed piano-stool ruthenium(<scp>ii</scp>) complexes
Govinda R. Navale, Sain Singh, Sonia Agrawal, Chandrachur Ghosh, Angshuman Roy Choudhury, Partha Roy, Dhiman Sarkar, Kaushik Ghosh
Abstract
) values for the antitubercular activity of Ru-1 and Ru-2 were 4.87 ± 1.32 μM and 5.78 ± 0.54 μM, respectively. A cytotoxic study of these complexes was performed against the human breast cancer cell line (MCF-7) and the human embryonic kidney cell line (HEK293) (normal cells). The study revealed meaningful activity of the Ru-1 complex against (cancer) MCF-7 cells, while the viability of HEK293 (normal) cells in the presence of Ru-2 was higher as compared to a reference drug 5FU. We suggest that these kinds of Ru-complexes could have potential for application in metallopharmaceuticals.
Topics & Concepts
RutheniumDNACombinatorial chemistryChemistryAntibacterial activityStereochemistryBiochemistryBiologyBacteriaGeneticsCatalysisMetal complexes synthesis and propertiesSynthesis and Biological EvaluationFerrocene Chemistry and Applications